2011 Annual Report
The OUTCOMES RESEARCH Group was formed in 1990 at the University of California in San Francisco and subsequently became an institute when the group's administrative center moved to the University of Louisville in March of 2000. In 2005, OUTCOMES RESEARCH became a department at the Cleveland Clinic. After 5.5 years, the Department of OUTCOMES RESEARCH now includes 54 members at the Clinic, among 111 academic investigators in fifteen countries including the Argentina, Austria, Belgium, Canada, China, Colombia, France, Germany, Hungary, Ireland, Israel, Italy, Japan, Romania, and the United States. The Consortium is non-profit; its only goal is thus participation in high-quality research.
The Consortium is currently involved in more than 100 clinical studies, including many large multi-center outcome trials. Much of the Consortium’s funding is from the National Institutes of Health and other peer-reviewed granting agencies. The Consortium facilitates scientific exchange and collaboration necessary for technically complex outcomes studies involving hundreds or thousands of patients. Additional information is available at www.OR.org.
Aspirations
OUTCOMES RESEARCH seeks to understand the end results of particular health care practices and interventions. End results include effects that people experience and care about, such as change in the ability to function. In particular, for individuals with chronic conditions—where cure is not always possible—end results include quality of life as well as mortality. By linking the care people get to the outcomes they experience, OUTCOMES RESEARCH has become the key to developing better ways to monitor and improve the quality of care.
The general goal of the OUTCOMES RESEARCH Consortium is to evaluate inexpensive, low-risk interventions that are easy to implement yet likely to markedly improve outcome. For example, we have shown that simply maintaining intraoperative normothermia markedly reduces the risk of complications — and does so at trivial cost. A consequence of our work is that active intraoperative warming has become routine, whereas it was rare a decade ago.
Mission
Be the world’s leading anesthesia-related clinical research organization.
Behaviors
Publish more high-impact, peer-reviewed clinical research papers (quantified as number times impact) than any other anesthesia organization.
Recruit more extra-mural clinical research funding than any other anesthesia organization, with “clinical research” being defined as research conducted with human subjects.
Train clinical investigators at all levels.
Personnel
Administrative Structure
Director: Daniel I. Sessler, M.D. Cleveland USA
Associate Director: Andrea Kurz, M.D. Cleveland USA
Site Directors
Anupama Wadhwa, M.D. Louisville USA
Donal Buggy, M.D. Dublin Ireland
Marcel Chauvin, M.D. Paris France
Tibi Ezri, M.D. Tel Aviv Israel
Edith Fleischmann, M.D. Vienna Austria
Kate Leslie, M.D. Melbourne Australia
Makoto Ozaki, M.D. Tokyo Japan
Adrian O. Alvarez, M.D. Buenos Aires Argentina
Peter Szmuk, M.D. Dallas USA
General Members
| Member | City | Country |
|---|---|---|
| Alaa A. Abd-Elsayed, M.D. | Cincinnati | USA |
| Basem B. Abdelmalak, M.D. | Cleveland | USA |
| Awais Ahmed, M.D. | Cleveland | USA |
| Ozan Akça, M.D. | Louisville | USA |
| Adrian O. Alvarez, M.D., Ph.D. | Buenos Aires | Argentina |
| Christian C. Apfel, M.D. | San Francisco | USA |
| Harendra Arora, M.D. | Chapel Hill | USA |
| Abdulkadir Atim, M.D. | Cleveland | USA |
| Ruth Aufderheide, B.A. | Cleveland | USA |
| Maria Bauer, M.D. | New York | USA |
| Allen Bashour, M.D. | Cleveland | USA |
| Albatoul Bensitel, M.D. | Cleveland | USA |
| Sergio D. Bergese, M.D. | Columbus | USA |
| Ethan Bernstein | Rochester | USA |
| Catherine J. Binkley, D.D.S., Ph.D. | Louisville | USA |
| Donal J. Buggy, M.D., FRCPI, FRCACSI, FRCA | Dublin | Ireland |
| Juan Cata, M.D. | Houston | USA |
| Nassib G. Chamoun, M.S. | Brookline | USA |
| Alexandra Chludzinski | Cleveland | USA |
| Kenneth Cummings, III, M.D. | Cleveland | USA |
| Jacek B. Cywinski, M.D. | Cleveland | USA |
| Jarrod E. Dalton, M.A. | Cleveland | USA |
| Stacie G. Deiner, M.D. | New York | USA |
| Armin Deroee, M.D. | Cleveland | USA |
| Anthony G. Doufas, M.D., Ph.D. | Stanford | USA |
| Andra I. Duncan, M.D. | Cleveland | USA |
| Cameron Egan | Cleveland | USA |
| Gamal Eid, M.D. | Cleveland | USA |
| Hesham Elsharkawy, M.D. | Cleveland | USA |
| Stefan Engelen, M.D. | Antwerp | Belgium |
| Yashar Eshraghi, M.D. | Cleveland | USA |
| Shmuel Evron, M.D. | Holon | Israel |
| Tibi Ezri, M.D. | Holon | Israel |
| Ehab S.A. Farag, M.D., F.R.C.A. | Cleveland | USA |
| Mary Federico | Cleveland | USA |
| Marc A. Feldman, M.D., M.H.S. | Cleveland | USA |
| Edith Fleischmann, M.D. | Vienna | Austria |
| Alex Fu | Cleveland | USA |
| Béla Fûlesdi, M.D., Ph.D. | Debrecen | Hungary |
| Maria Ignacia Gazmuri-Arrieta, M.D. | Cleveland | USA |
| Michael M.N. Ghobrial, M.D. | Cleveland | USA |
| Klesta K. Gjini, M.B.A. | Cleveland | USA |
| Martin V. Grady, M.D. | Mayfield Heights | USA |
| J. Steven Hata, M.D., F.C.C.P., M.S.C. | Cleveland | USA |
| Christine E. Hillegas | Cleveland | USA |
| Hooman Honar, M.D. | Cleveland | USA |
| Ernst-Peter Horn, M.D. | Hamburg | Germany |
| Pedro F. Ibarra, M.D. | Bogota | Colombia |
| Brian M. Ilfeld, M.D., M.S. | San Diego | USA |
| Steven R. Insler, D.O. | Cleveland | USA |
| Daniela C. Ionescu, Ph.D., D.E.A.A. | Cluj-Napoca | Romania |
| Crissy Irani, C.T. | Cleveland | USA |
| Barbara Kabon, M.D. | Vienna | Austria |
| Yusuke Kasuya, M.D. | Tokyo | Japan |
| Roop Kaw, M.D. | Cleveland | USA |
| Oliver Kimberger, M.D. | Vienna | Austria |
| Ryu Komatsu, M.D. | Cleveland | USA |
| Priya A. Kumar, M.D. | Chapel Hill | USA |
| Andrea M. Kurz, M.D. | Cleveland | USA |
| Giovanni Landoni, M.D. | Milan | Italy |
| Jae H. Lee, B.S. | Cleveland | USA |
| Rainer Lenhardt, M.D. | Louisville | USA |
| Kate Leslie, M.D., F.A.N.Z.C.A. | Parkville | Australia |
| Jinbo Liu, M.D. | Cleveland | USA |
| Edwin B. Liem, M.D. | Louisville | USA |
| Ngai Liu, M.D., Ph.D. | Suresnes | France |
| Ankit Maheshwari, M.D. | Cleveland | USA |
| Edward J. Mascha, Ph.D. | Cleveland | USA |
| Takashi Matsukawa, M.D. | Chuo | Japan |
| Rachel E. McKay, M.D. | San Franscisco | USA |
| Maria Mendoza-Cuartas, M.D. | Cleveland | USA |
| Scott A. Miller, M.D. | Winston Salem | USA |
| Toshiki Mizobe, M.D., Ph.D. | Kyoto | Japan |
| Yasufumi Nakajima, M.D., Ph.D. | Kyoto | Japan |
| Edward M. Noguera, M.D. | Cleveland | USA |
| Detlef E.R. Obal, M.D., D.E.S.A. | Louisville | USA |
| Mirela Ovreiu, Ph.D. | Cleveland | USA |
| Makoto Ozaki, M.D., Ph.D. | Tokyo | Japan |
| Marie-Odile Parat, Pharm.D., Ph.D. | Woolloongabba | Australia |
| Ivan Parra-Sanchez, M.D. | Cleveland | USA |
| Silvia E. Perez-Protto, M.D. | Cleveland | USA |
| Olga M. Plattner, M.D. | Vienna | Austria |
| Radu B. Pop, M.S. | Dallas | USA |
| Stefan Rauch, M.D. | Louisville | USA |
| Luke Reynolds, M.Sc. | Halifax | Canada |
| David A. Rincón-Valenzuela, M.D., M.Sc. | Bogotá | Colombia |
| Kurt Ruetzler, M.D. | Vienna | Austria |
| Leif Saager, M.D. | Cleveland | USA |
| Vafi Salmasi, M.D. | Cleveland | USA |
| Sheryar Sarwar, M.D. | Cleveland | USA |
| Hiroaki Sato, M.D. | Yamanashi | Japan |
| Tamaki Sato, M.D. | Yamanashi | Japan |
| Thomas P. Schricker, M.D., Ph.D. | Montreal | Canada |
| Daniel I. Sessler, M.D. | Cleveland | USA |
| Ayako Shiba, M.D. | Minato-ku | Japan |
| Jeffrey H. Silverstein, M.D. | New York | USA |
| Tanya Smith, B.A. | Cleveland | USA |
| Thilak Sreenivasalu, M.D. | Cleveland | USA |
| Wolf Stapelfeldt, M.D. | Cleveland | USA |
| Jeff W. Steiner, D.O. | Dallas | USA |
| Peter Szmuk, M.D. | Dallas | USA |
| Tanja A. Treschan, M.D. | Dûsseldorf | Germany |
| Elena Trimbitas, B.B.A. | Cleveland | USA |
| Alparslan Turan, M.D. | Cleveland | USA |
| Belinda Udeh, Ph.D. | Cleveland | USA |
| Gretchen Upton, B.S. | Cleveland | USA |
| Tamás Végh, M.D. | Debrecen | Hungary |
| Anupama Wadhwa, M.D. | Louisville | USA |
| Jiang Wu, M.D. | Cleveland | USA |
| Dongsheng Yang, M.S. | Cleveland | USA |
| Jean-Pierre Yared, M.D. | Cleveland | USA |
| Jing You, M.S. | Cleveland | USA |
| Erich M. Zirzow, E.M.T.-P., C.C.R.P. | Cleveland | USA |
| Yunxia Zuo, Ph.D., M.D. | Chengdu | China |
Research Fellows
| Name | Origin | Dates | Subsequent Position |
|---|---|---|---|
| Angela Bonilla, M.D. | Colombia | 2008-11 | Internship, NEOUCOM, Case Western |
| Ivan Parra-Sanchez, M.D. | Colombia | 2008-11 | Anesthesia Resident, Cleveland Clinic |
| Maria Bauer, M.D. | Hungary | 2009-11 | Anesthesia Resident, Cornell University |
| Thilak Sreenivasulu, M.D. | India | 2009-11 | Anesthesia Resident, Cleveland Clinic |
| Armin Deroee, M.D. | Iran | 2010-11 | Anesthesia Resident, Cleveland Clinic |
| Vafi Salmasi, M.D. | Iran | 2011 | Anesthesia Resident, Cleveland Clinic |
| Awais Ahmed, M.D. | Pakistan | 2011-12 | Medicine Resident, Univ. of Canton |
| Yashar Eshraghi, M.D. | Iran | 2011-12 | Anesthesia Resident, Metro Hospital |
| Michael M. N. Ghobrial, M.D. | Egypt | 2011-12 | Medicine, Fairview, Cleveland Clinic |
| Crissy Irani, C.T. | United States | 2010-11 | Returned to India for family reasons |
| Sunitha Kanchi-Kandadai | 2010-11 | Anesthesia Resident, Univ. Louisville | |
| Sheryar Sarwar, M.D. | Netherlands | 2010- | |
| Albatoul Bensitel, M.D. | Morocco | 2010- | |
| Abdulkadir Atim, M.D. | Turkey | 2010- | |
| Hooman Honar, M.D. | Iran | 2010- | |
| Gamal Eid, M.D. | Egypt | 2010- | |
| Sahil Chhabra |
Graduate Students (full year)
| Name | Dates | Institution |
|---|---|---|
| Alexandra Chludzinski, B.S. | 2010-11 | Cleveland Clinic Lerner College of Medicine |
| Alex Fu, B.S. | 2010-2011 | Case Western University School of Medicine |
| Stephanie Weiss, Ph.D. | 2010-11 | Cleveland Clinic Lerner College of Medicine |
| Cameron Egan, B.S. | 2011- | University of Rochester |
Residents and Medical Students
| Name | Dates | Institution |
|---|---|---|
| Brian Hesler | 10/2011- | Cleveland Clinic Anesthesia Residency |
| Worasak Keeyapaj | 10/2010-03/2011 | Cleveland Clinic Anesthesia Residency |
| Michael Schnetz | 05/2011-08/2011 | Case Western School of Medicine |
| Danyal Shaikh | 05/2011-07/2011 | Case Western School of Medicine |
| Jaspreet Somal | 08/2011- | Cleveland Clinic Anesthesia Residency |
Honors and Awards
| Name | Honor |
|---|---|
| Alaa Abd-Elsayed | 1st place, research study, Ohio Society of Anesthesia |
| Alaa Abd-Elsayed | 1st place, case report, Ohio Society of Anesthesia |
| Maria Bauer | 3rd place, patient safety, MARC |
| Albatoul Bensitel | BUMPUS Award |
| Ankit Maheshwari | 2nd place, clinical pharmacology, MARC |
| Maria Mendoza-Cuartes | 1st place, clinical pharmacology, MARC |
| Ivan Parra-Sanchez | 1st place, Regional, MARC |
| Vafi Salmasi | BUMPUS Award |
| Daniel Sessler | Bernard Eliasberg Award |
| Daniel Sessler | Rovenstine Lecture, NY Postgraduate Assembly |
| Daniel Sessler | Appointed Editor, Anesthesiology |
| David Rincón-Valenzuela | 2nd place, Luis Cerezo Award (Colombian Society of Anesthesia) |
Consortium Research Awards
The Gladys Sessler Prize is an endowed award that is given yearly. All research fellows and junior faculty members of the OUTCOMES RESEARCH Consortium are eligible. This year’s award was given to Kurt Ruetzler, M.D. for his outstanding contributions to numerous studies of thermoregulation and airway management.
The Best Fellow Award is given to the the Department of OUTCOMES RESEARCH fellow who is voted by the faculty to have performed at the very highest level. This year’s award was given to Armin Deroee, M.D. for his remarkable contributions to several studies, most notably POISE-2 which is an international study of 10,000 patients who are being factorially randomized to aspirin and/or clonidine.
Active Grants
Funded Research - Peer Reviewed Sources
| Peer-Reviewed Sources | Agency | Principal Investigator | Direct cost ($) | Dates |
|---|---|---|---|---|
| Remote Impact | Canadian Institutes of Health Research | Duncan | 33,747 | 2011- 16 |
| Evaluation of Multisource Feedback in Professionalism for Anesthesia Residents | FAER | Riveros-Perez | 100,000 | 2011-12 |
| Anesthesia Summer Research Fellowship | FAER medical student fellowship | Schnetz | 4,200 | 2011 |
| HIP ATTACK: Hip fracture accelerated surgical treatment and care track | Hamilton Academic Health Sciences | Bhandari | 130,000 | 2011-12 |
| NeuroVISION: Neurological impact of vascular events in noncardiac surgery patients cohort evaluation | Canadian Institutes of Health Research | Mrkobrada | 85,000 | 2011-12 |
| Danyal Shaikh- NIHLB | NIHLB (R25HL103152) | Sessler | 1,051 | 2011- 12 |
| Steroids in Cardiac Surgery | PHRI- Canada | Yared | 78,250 | 2010-15 |
| Hyperinsulinemic glucose control and myocardial function during cardiac surgery | National Institutes of Health (K23HL093056 ) | Duncan | 493,000 | 2010-15 |
| PeriOperative ISchemic Evaluation-2 | Canadian Institutes of Health Research | Kurz | 512,000 | 2010-14 |
| A Comparison of Epidural Analgesia and Traditional pain management | Case Western Reserve University | Cummings | 4,280 | 2010- 12 |
| Non-Contact ECG Monitoring ad Diagnosis | Cleveland State University | Ovreiu | 17,359 | 2010- 12 |
| Classification of atrial fibrillation prone patients using neuro-fuzzy modeling | American Heart Association | Ovreiu | 100,000 | 2010-11 |
| Assessment of Long-Term Neurodevelopmental Outcomes in Pediatric Patients Administered Regional and General Anesthesia as Neonates or Infants | National Institutes of Health (R01HD061336) | Szmuk | 117,493 | 2010-15 |
| Effect of intrathecal ketorolac on mechanical hypersensitivity following surgery | National Institutes of Health (GM048085) | Eisenach | 119,312 | 2009-11 |
| POCD | National Institutes of Health | Sessler | 320,422 | 2007- 12 |
List includes grants on which an OUTCOMES RESEARCH Consortium member is a co-investigator; many are large multi-center projects in which the member investigator has a limited role. Amounts shown are totals for multi-year projects; funding for the current year is considerably less.
Corporate Sources
For collaborative projects, only funds controlled by OUTCOMES RESEARCH are included
| Corporate Sources | Agency | Principal Investigator | Direct cost ($) | Dates |
|---|---|---|---|---|
| Unrestricted educational grant | Hospira | Sessler | 9,500 | 2011 |
| Incident of Perioperative Anaphylactic Reactions | Merck & Co Inc | Saager | 234,025 | 2011-12 |
| Effect of Goal- Directed Crystalloid versus Colloid Administration | Hospira | Kurz | 124,875 | 2011- 12 |
| A Multi Center Randomized open- Label Surgical Surveillance | Cumberland Pharmaceutical | Turan | 53,307 | 2011- 16 |
| The Effects of Dexmedetomidine and propofol on Cerebral Blood | Hospira | Farag | 108,904 | 2010-12 |
| Remifentanil versus Dexmedetomidine the best anesthetix strategy | Hospira | Rajan | 19,700 | 2010- 12 |
| Postoperative outcomes in Patients who receive Dexmedetonidine | Hospira | Turan | 18,500 | 2010- 12 |
| Deep temperature monitor evaluation | Arizant Healthcare | Sessler | 96,918 | 2009-11 |
| Multi-Center Open Label Pediatric Oxymorphone Solution Trial | Endo | Szmuk | 199,726 | 2011-12 |
| Open-Label PK/Safety of Oxycodone Q12H in Pediatric Surgical Patients | Purdue | Szmuk | 15,445 | 2010-11 |
| Open-Label Safety of Oxycodone Q12H in Pediatric Opioid Tolerant Patients | Purdue | Szmuk | 53,983 | 2011- 12 |
| Open-Label PK/Safety of Oral Morphine in Pediatric Surgical Patients | Roxane | Szmuk | 42,817 | 2010-12 |
| Use of Rainbow Acoustic Monitor in Pediatric Patients | Masimo | Szmuk | 13,172 | 2011- 12 |
| Exploratory method-comparison evaluation of a disposable zero-heat flow thermometry system. | Arizant Inc (USA) | Sessler | 95,724 | 2009-11 |
| Dexlerium POCD | Aspect Medical | Sessler | 53,800 | 2009-14 |
| BIS and long-term outcomes | Aspect Medical | Sessler | 1,730,000 | 2009-13 |
| ASPECT Medical Data Collaborating Agreement | Aspect Medical | Sessler | 146,154 | 2008-13 |
| Breast Cancer Recurrence | Aspect Medical | Sessler | 63,461 | 2008-13 |
| Accuracy of the Drager Dual Sensor Temperature Measurement | Dragerwerk AG & Co KgaA | Kurz | 46,154 | 2008- 11 |
| Dexlerium POCD | Aspect Medical | Sessler | 53,800 | 2009-14 |
List includes grants on which an OUTCOMES RESEARCH Consortium member is a co-investigator; many are large multi-center projects in which the member investigator has a limited role. Amounts shown are totals for multi-year projects; funding for the current year is considerably less.
Publications
Citations
Consortium papers are cited >1,300 times per year. Among these, >500 citations per year are to papers in Anesthesiology and 275 are to Anesth Analg. 26 consortium papers have been cited more than 100 times; 66 others have been cited more than 50 times.
Contribution to the world’s literature
There are about 1,200 anesthesia clinical research papers published each year. The Consortium published about 55 full papers last year. OUTCOMES RESEARCH is thus responsible for nearly 5% of the world’s clinical research in anesthesia. As our publications are usually highly ranked, the effective contribution is actually considerably greater.
This year’s featured paper
Cummings KC, 3rd, Napierkowski DE, Parra-Sanchez I, Kurz A, Dalton JE, Brems JJ, Sessler DI: Effect of dexamethasone on the duration of interscalene nerve blocks with ropivacaine or bupivacaine. Br J Anaesth 2011; 107: 446-53.
Background: Pain after shoulder surgery is often treated with interscalene nerve blocks. Single-injection blocks are effective, but time-limited. Adjuncts such as dexamethasone may help. We thus tested the hypothesis that adding dexamethasone significantly prolongs the duration of ropivacaine and bupivacaine analgesia and that the magnitude of the effect differs among the two local anaesthetics.
Methods: In a double-blinded trial utilizing single-injection interscalene block, patients were randomized to one of four groups: (i) ropivacaine: 0.5% ropivacaine; (ii) bupivacaine: 0.5% bupivacaine; (iii) ropivacaine and steroid: 0.5% ropivacaine mixed with dexamethasone 8 mg; and (iv) bupivacaine and steroid: 0.5% bupivacaine mixed with dexamethasone 8 mg. The primary outcome was time to first analgesic request after post-anaesthesia care unit discharge. The Kaplan-Meier survival density estimation and stratified Cox's proportional hazard regression were used to compare groups.
Results: Dexamethasone significantly prolonged the duration of analgesia of both ropivacaine [median (inter-quartile range) 11.8 (9.7, 13.8) vs 22.2 (18.0, 28.6) h, log-rank P<0.001] and bupivacaine [14.8 (11.8, 18.1) and 22.4 (20.5, 29.3) h, log-rank P<0.001]. Dexamethasone prolonged analgesia more with ropivacaine than bupivacaine (Cox's model interaction term P=0.0029).
Conclusion: Dexamethasone prolongs analgesia from interscalene blocks using ropivacaine or bupivacaine, with the effect being stronger with ropivacaine. However, block duration was longer with plain bupivacaine than ropivacaine. Thus, although dexamethasone prolonged the action of ropivacaine more than that of bupivacaine, the combined effect of dexamethasone and either drug produced nearly the same 22 h of analgesia.
Published Full Papers
1. Abd-Elsayed A, Barsoum W, Bell G, guirguis M, Farag E: Diplopia Following Spine Surgery: A Case Series. The Open Neurosurgery Journal 2011; 4
2. Abd-Elsayed A, Seifc J, Guirguisc M, Zacky S, Mounir-Solimanc L: Bilateral brachial plexus home going catheters after digital amputation for patient with upper extremity digital gangrene. J Clin Med Res 2011; 3: 325-7
3. Abdallah R, Galway U, You J, Kurz A, Sessler DI, Doyle DJ: A randomized comparison between the Pentax AWS Video Laryngoscope and the Macintosh laryngoscope in morbidly obese patients. Anesth Analg 2011; 113: 1082-7
4. Abdelmalak B, Jagannathan N, Arain FD, Cymbor S, McLain R, Tetzlaff JE: Electromagnetic interference in a cardiac pacemaker during cauterization with the coagulating, not cutting mode. Journal of anaesthesiology, clinical pharmacology 2011; 27: 527-30
5. Abdelmalak B, Maheshwari A, Kovaci B, Mascha EJ, Cywinski JB, Kurz A, Kashyap VS, Sessler DI: Validation of the DeLiT Trial intravenous insulin infusion algorithm for intraoperative glucose control in noncardiac surgery: a randomized controlled trial. Can J Anaesth 2011; 58: 606-16
6. Abdelmalak BB, Bernstein E, Egan C, Abdallah R, You J, Sessler DI, Doyle DJ: GlideScope vs flexible fibreoptic scope for elective intubation in obese patients. Anaesthesia 2011; 66: 550-5
7. Afsharimani B, Cabot P, Parat M-O: Morphine and tumor growth and metastasis. Cancer and Metastasis Reviews 2011
8. Argalious MY, Dalton JE, Mascha EJ, Cywinski JB, Clair DG: Association of red blood cell transfusion and postoperative outcomes after endovascular aortic repair. Seminars in cardiothoracic and vascular anesthesia 2011; 15: 49-55
9. Bignami E, Landoni G, Gerli C, Testa V, Mizzi A, Fano G, Nuzzi M, Franco A, Zangrillo A: Sevoflurane vs. propofol in patients with coronary disease undergoing mitral surgery: a randomised study. Acta Anaesthesiol Scand 2011
10. Biondi-Zoccai G, Landoni G, Modena MG: A journey into clinical evidence: from case reports to mixed treatment comparisons. HSR Proceedings in Intensive Care and Cardiovascular Anesthesia 2011; 3: 93-6
11. Boaz M, Iskhakov A, Tsivian A, Shimonov M, Berkenstadt H, Izakson A, Szmuk P, Evron S, Muggia M, Ezri T: Perioperative metabolic alkalemia is more frequent than metabolic acidemia in major elective abdominal surgery. Journal of clinical monitoring and computing 2011; 25: 223-30
12. Cata JP, Abdelmalak B, Farag E: Neurological biomarkers in the perioperative period. Br J Anaesth 2011; 107: 844-58
13. Cata JP, Klein EA, Hoeltge GA, Dalton JE, Mascha E, O'Hara J, Russell A, Kurz A, Ben-Elihayhu S, Sessler DI: Blood storage duration and biochemical recurrence of cancer after radical prostatectomy. Mayo Clin Proc 2011; 86: 120-7
14. Cummings KC, 3rd, Napierkowski DE, Parra-Sanchez I, Kurz A, Dalton JE, Brems JJ, Sessler DI: Effect of dexamethasone on the duration of interscalene nerve blocks with ropivacaine or bupivacaine. Br J Anaesth 2011; 107: 446-53
15. Cywinski JB, Mascha EJ, You J, Sessler DI, Kapural L, Argalious M, Parker BM: Pre-transplant MELD and sodium MELD scores are poor predictors of graft failure and mortality after liver transplantation. Hepatology international 2011; 5: 841-9
16. Dalton JE, Kurz A, Turan A, Mascha EJ, Sessler DI, Saager L: Development and Validation of a Risk Quantification Index for 30-Day Postoperative Mortality and Morbidity in Noncardiac Surgical Patients. Anesthesiology 2011; 114: 1336-44
17. Duan X, Wu D, Bautista, Akca, Carter, Latif: Assessment of reaching proficiency in procedural skills: fiberoptic airway simulator training in novices. Open Access Medical Statistics 2011; 1: 45-50
18. Ecimovic P, Murray D, Doran P, McDonald J, Lambert DG, Buggy DJ: Direct effect of morphine on breast cancer cell function in vitro: role of the NET1 gene. Br J Anaesth 2011; 107: 916-23
19. Egan C, Bernstein E, Reddy D, Ali M, Paul J, Yang D, Sessler DI: A randomized comparison of intraoperative PerfecTemp and forced-air warming during open abdominal surgery. Anesth Analg 2011; 113: 1076-81
20. Engelen S, Himpe D, Borms S, Berghmans J, Van Cauwelaert P, Dalton JE, Sessler DI: An evaluation of underbody forced-air and resistive heating during hypothermic, on-pump cardiac surgery. Anaesthesia 2011; 66: 104-10
21. Ezri T, Lurie S, Weiniger CF, Golan A, Evron S: Cardiopulmonary resuscitation in the pregnant patient--an update. IMAJ 2011; 13: 306-10
22. Farag E, Argalious M, Sessler DI, Kurz A, Ebrahim ZY, Schubert A: Use of alpha-2 agonists in neuroanesthesia. An overview. Ochsner Journal 2011; 11: 57-69
23. Farag E, Manno EM, Kurz A: Use of hypothermia for traumatic brain injury: point of view. Minerva Anestesiol 2011; 77: 366-70
24. Hata JS, Simmons JS, Kumar AB, Rickelman JH, Nickel EJ, Simmons ST, Torner J: The Acute Effectiveness and Safety of the Constant-Flow, Pressure-Volume Curve to Improve Hypoxemia in Acute Lung Injury. Journal of Intensive Care Medicine 2011
25. Hodd JA, Doyle DJ, Gupta S, Dalton JE, Cata JP, Brewer EJ, James M, Sessler DI: A mannequin study of intubation with the AP Advance and GlideScope Ranger videolaryngoscopes and the macintosh laryngoscope. Anesth Analg 2011; 113: 791-800
26. Ilfeld BM, Shuster JJ, Theriaque DW, Mariano ER, Girard PJ, Loland VJ, Meyer RS, Donovan JF, Pugh GA, Le LT, Sessler DI, Ball ST: Long-Term Pain, Stiffness, and Functional Disability After Total Knee Arthroplasty With and Without an Extended Ambulatory Continuous Femoral Nerve Block. Reg Anesth Pain Med 2011; 36: 116-20
27. Kavsak PA, Walsh M, Srinathan S, Thorlacius L, Buse GL, Botto F, Pettit S, McQueen MJ, Hill SA, Thomas S, Mrkobrada M, Alonso-Coello P, Berwanger O, Biccard BM, Cembrowski G, Chan MT, Chow CK, de Miguel A, Garcia M, Graham MM, Jacka MJ, Kueh JH, Li SC, Lit LC, Martinez-Bru C, Naidoo P, Nagele P, Pearse RM, Rodseth RN, Sessler DI, Sigamani A, Szczeklik W, Tiboni M, Villar JC, Wang CY, Xavier D, Devereaux PJ: High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study. Clin biochem 2011
28. Kaw R, Gali B, Collop N: Perioperative Care of Patients with Obstructive Sleep Apnea, in press. Current Treatment Options in Neurology 2011
29. Kaw R, Gali B, Collop NA: Perioperative care of patients with obstructive sleep apnea. Current treatment options in neurology 2011; 13: 496-507
30. Kaw R, Hernandez AV, Masood I, Gillinov AM, Saliba W, Blackstone EH: Short- and long-term mortality associated with new-onset atrial fibrillation after coronary artery bypass grafting: A systematic review and meta-analysis. The Journal of thoracic and cardiovascular surgery 2011; 141: 1305-12
31. Kaw R, Pasupuleti V, Walker E, Ramaswamy A, Foldvary-Schafer N: Postoperative Complications in Patients with Obstructive Sleep Apnea. Chest 2011
32. Khazin V, Weitzman S, Rozenzvit-Podles E, Ezri T, Debby A, Golan A, Evron S: Postoperative analgesia with tramadol and indomethacin for diagnostic curettage and early termination of pregnancy. International journal of obstetric anesthesia 2011; 20: 236-9
33. Komatsu R, Kamata K, You J, Sessler DI, Kasuya Y: Airway scope for tracheal intubation in the lateral position. Anesth Analg 2011; 112: 868-74
34. Liu N, Chazot T, Hamada S, Landais A, Boichut N, Dussaussoy C, Trillat B, Beydon L, Samain E, Sessler DI, Fischler M: Closed-loop coadministration of propofol and remifentanil guided by bispectral index: a randomized multicenter study. Anesth Analg 2011; 112: 546-57
35. Mascha EJ, Sessler DI: Equivalence and noninferiority testing in regression models and repeated-measures designs. Anesth Analg 2011; 112: 678-87
36. Mascha EJ, Sessler DI: Design and analysis of studies with binary-event composite endpoints. Anesth Analg 2011; 112: 1461-71
37. Myles PS, Peyton P, Silbert B, Hunt J, Rigg JR, Sessler DI: Perioperative epidural analgesia for major abdominal surgery for cancer and recurrence-free survival: randomised trial. BMJ 2011; 342: d1491
38. Rigini N, Boaz M, Ezri T, Evron S, Trigub D, Jackobashvilli S, Izakson A: Prompt correction of endotracheal tube positioning after intubation prevents further inappropriate positions. Journal of Clinical Anesthesia 2011; 23: 367-71
39. Roberman D, Arora H, Sessler DI, Ritchey M, You J, Kumar P: Combined versus sequential injection of mepivacaine and ropivacaine for supraclavicular nerve blocks. Reg Anesth Pain Med 2011; 36: 145-50
40. Roder G, Sessler DI, Roth G, Schopper C, Mascha EJ, Plattner O: Intra-operative rewarming with Hot Dog resistive heating and forced-air heating: a trial of lower-body warming. Anaesthesia 2011; 66: 667-74
41. Ruetzler K, Gruber C, Nabecker S, Wohlfarth P, Priemayr A, Frass M, Kimberger O, Sessler DI, Roessler B: Hands-off time during insertion of six airway devices during cardiopulmonary resuscitation: A randomised manikin trial. Resuscitation 2011
42. Ruetzler K, Grubhofer G, Schmid W, Papp D, Nabecker S, Hutschala D, Lang G, Hager H: Randomized clinical trial comparing double-lumen tube and EZ-Blocker for single-lung ventilation. Br J Anaesth 2011; 106: 896-902
43. Ruetzler K, Kovaci B, Guloglu E, Kabon B, Fleischmann E, Kurz A, Mascha E, Dietz D, Remzi F, Sessler DI: Forced-air and a novel patient-warming system (vitalHEAT vH2) comparably maintain normothermia during open abdominal surgery. Anesth Analg 2011; 112: 608-14
44. Saager L, Kurz A, Deogaonkar A, You J, Mascha EJ, Jahan A, Turner PL, Sessler DI, Turan A: Pre-existing do-not-resuscitate orders are not associated with increased postoperative morbidity at 30 days in surgical patients. Crit Care Med 2011; 39: 1036-41
45. Sessler DI, Kurz A, Saager L, Dalton JE: Operation timing and 30-day mortality after elective general surgery. Anesth Analg 2011; 113: 1423-8
46. Sessler DI, Olmsted RN, Kuelpmann R: Forced-air warming does not worsen air quality in laminar flow operating rooms. Anesth Analg 2011; 113: 1416-21
47. Taniguchi Y, Lenhardt R, Sessler DI, Kurz A: The effect of altering skin-surface cooling speeds on vasoconstriction and shivering thresholds. Anesth Analg 2011; 113: 540-4
48. Turan A, Mascha EJ, Roberman D, Turner PL, You J, Kurz A, Sessler DI, Saager L: Smoking and perioperative outcomes. Anesthesiology 2011; 114: 837-46
49. Turan A, Mendoza ML, Gupta S, You J, Gottlieb A, Chu W, Saager L, Sessler DI: Consequences of succinylcholine administration to patients using statins. Anesthesiology 2011; 115: 28-35
50. Turan A, Sen H, Sizlan A, Yanarates O, Ozkan S, Koyuncu O, Dagli G: Dexmedetomidine: an alternative for epidural anesthesia in tension-free vaginal-tape surgery. Journal of Anesthesia 2011
51. Turner PL, Saager L, Dalton J, Abd-Elsayed A, Roberman D, Melara P, Kurz A, Turan A: A nomogram for predicting surgical complications in bariatric surgery patients. Obesity surgery 2011; 21: 655-62
52. Ucak A, Onan B, Sen H, Selcuk I, Turan A, Yilmaz AT: The effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgery. Journal of Cardiothoracic and Vascular Anesthesia 2011; 25: 824-9
53. Wadhwa A, Kandadai SK, Tongpresert S, Obal D, Gebhard RE: Ultrasound guidance for deep peripheral nerve blocks: a brief review. Anesthesiology research and practice 2011; 2011: 262-070
54. Ionescu D, Margarit S, Hadade A, Mocan T, Cristea V, Szederjest J: The effects of a small dose of dexamethasone on cell adhesion molecules during laparoscopic cholecystectomy. Drugs R D 2011; 11:309-316
55. Kasuya Y, Hargett JL, Lenhardt R, Heine MF, Doufas AG, Remmel KS, Ramirez JA, Akca O: Ventilator-associated pneumonia in critically ill stroke patients: frequency, risk factors, and outcomes. J Crit Care 2011; 26: 273-9
Full Papers in press
1. Liu N, Le Guen M, Benabbes-Lambert F, Chazot T, Trillat B, Sessler DI, Fischler M: Feasibility of closed-loop titration of propofol and remifentanil guided by the spectral M-entropy monitor. Anesthesiology
2. Cata JP, Gottumukkala V, Sessler DI: How regional analgesia might reduce postoperative cancer recurrence. Eur J Pain
3. Wu J, You J, Yerian L, Shiba A, Schauer PR, Sessler DI: Prevalence of liver steatosis and fibrosis and the diagnostic accuracy of ultrasound in bariatric surgery patients. Obesity Surg
4. Bauer M, Wang L, Onibonoje OK, Parrett C, Sessler DI, Mounier-Soliman L, Zaky S, Krebs V, Buller LT, Donohue MC, Stevens-Lapsley JE, Ilfeld BM. Continuous femoral nerve blocks: relative effects of local anesthetic dose, concentration and volume. Anesthesiology
5. Turan A, You J, Shiba A, Kurz A, Saager L, Sessler DI: Angeiotensin converting enzyme inhibitors are not associated with respiratory complications or mortality after non-cardiac surgery. Anesth Analg
6. Turan A, Mascha E, You J, Kurz A, Shiba A, Saager L, Sessler DI: Association between nitrous oxide and postoperative mortality and morbidity after non-cardiac surgery. Anesth Analg
7. Parra-Sanches I, Abdallah R, You J, Fu AZ, Grady M, Cummings K, Apfel C, Sessler DI: A time-motion economic analysis of postoperative nausea and vomiting in ambulatory surgery. Can J Anesth
8. Abd-Elsayed AA, Sessler DI, Mendoza-Cuartas M, Dalton JE, Said T, Meinert J, Upton G, Franklin C, Kurz A: A randomized controlled study to assess patient understanding of and consenting for clinical trials using different consent form presentations. Minerva Anestesiologica
9. Farag E, Sessler DI, Kovaci B, Wang L, Mascha EJ, Bell G, Kalfas I, Rockwood E, Kurz A: The effects of crystalloid versus colloid and the alpha-2 agonist brimonidine versus placebo on intraocular pressure during prone spine surgery: a factorial randomized trial. Anesthesiology
10. Rauch S, Krueger K, Turan A, You J, Roewer N, Sessler DI: Use of wireless motility capsule to determine gastric emptying and small intestinal transit times in critically ill patients. J Crit Care
11. Farag E, Abd-Elsayed AA, Anderson M, Abdelmalak J, Schubert A. Anesthetic management for wingspan stent. The Ochsner Journal
12. Abdelmalak B, Gildea T, Doyle J. Anesthesia For Bronchoscopic Surgery. Current Pharmaceutical Design
13. Abdelmalak B, Ibrahim M, Yared JP, Modic M,Nasr C. Perioperative Glycemic Management In Insulin Pump Patients Undergoing Noncardiac Surgery. Current Pharmaceutical Design
14. Xiao-Qiang Li, Yue’E Dai, Yun-Xia Zuo. Childrens seizures caused by continuous intravenous infusion of tramadol analgesia: two rare case reports. Ped Anesth
15. Shimonov M, Protianov M, Blecher, M, Schachter, Ezri, T: Hemodynamic effects of laparoscopic radiofrequency ablation of liver tumors versus laparoscopic hepatic ultrasound examination. J Clin Anesth
16. Végh T, Juhász M, Enyedi A, Takács I, Kollár J, Fülesdi B: Clinical experience with a new endobrochial blocker: the EZ-blocker. J Anaesth
17. Cheng J, Pope JE, Dalton JE, Cheng O, Bensitel A: Comparative outcomes of cooled versus traditional radiofrequency ablation of the lateral branches for sacroiliac joint pain. Clin J Pain
18. Rincón-Valenzuela D, Benavides-Caro A: Oxigeno suplementario intraoperatorio para disminuir morbimortalidad en anestesia general: revisión sistemática y meta-análisis de experimentos controlados aleatorizados. Revista Colombiana de Anestesiologia
19. Steiner JW, Pop R, You J, Hoang SQ, Whitten CW, Barden C, Szmuk P: Anesthesiology residents’ medical school debt influence on moonlighting activities, work environment choice, and debt repayment programs: a nationwide survey. Anesth Analg
20. Latif RK, Bautista AF, Memon SB, Smith EA, Wang C, Wadhwa A, Carter MB, Akça O: Teaching aspetic technique for central venous access under ultrasound guidance: A randomized trial comparing didactic training alone to didactic plus simulation-based training. Anesth Analg
